Four Commonly Ignored Signs of Vitamin B6 Deficiency

Introduction

Vitamins play an essential role in maintaining overall health, and Vitamin B6—also known as pyridoxine—is no exception. This water-soluble vitamin helps the body produce neurotransmitters, hemoglobin, and enzymes that regulate metabolism. Additionally, it is essential for brain development and immunological function.

Despite its importance, many people don’t get enough Vitamin B6 from their diet. Deficiency is more common in the elderly, individuals with kidney problems, those who drink excessive alcohol, and people taking certain medications. Unfortunately, the early signs of deficiency can be subtle, often mistaken for stress or minor health issues. If left untreated, Vitamin B6 deficiency can affect both physical and mental health.

This article explores four symptoms of Vitamin B6 deficiency that are often ignored, along with explanations of why they occur, and how you can prevent or manage them.

1. Cracked and Sore Lips (Cheilitis)

Cheilitis, or painful cracks or sores around the corners of the mouth, is one of the first and most obvious symptoms of a vitamin B6 deficiency. The skin may appear red, swollen, or scaly, and in severe cases, the cracks may bleed.

Why it happens:
Vitamin B6 is necessary for producing hemoglobin and neurotransmitters that influence skin and tissue health. A deficiency weakens the skin’s protective barrier, making it more prone to inflammation and infection.

How it affects daily life:
Cheilitis can make it painful to smile, eat acidic foods, or even speak. Many people mistake it for a fungal infection or weather-related dryness, delaying proper treatment.

What to do:
Including more B6-rich foods—such as chicken, tuna, bananas, and fortified cereals—can help heal these sores. In stubborn cases, supplements may be needed.

2. Irritability, Depression, and Mood Changes

Mental health is strongly linked to Vitamin B6 levels. This vitamin plays a crucial role in synthesizing neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA). When B6 is lacking, these “mood-regulating chemicals” drop, leading to psychological symptoms.

Why it happens:

• Serotonin regulates mood and sleep. Without enough of it, people may feel anxious or depressed.
• Dopamine affects motivation and pleasure. Low levels can cause irritability and fatigue.
• GABA reduces stress and promotes relaxation. Deficiency may result in heightened nervousness or insomnia.

How it shows up:
People with B6 deficiency often report sudden mood swings, irritability, and difficulty managing stress. In severe cases, depression and confusion may develop.

What to do:
Addressing deficiency through diet and supplementation can restore balance. Foods like salmon, turkey, potatoes, and sunflower seeds support mental well-being. For those with persistent symptoms, professional medical and psychological support is recommended.